List of publications

Drosophila and drugs

Wolf FW, Eddison , Lee S, Cho W, Heberlein U (2007) GSK-3/Shaggy regulates olfactory habituation in Drosophila. Proc Natl Acad Sci USA 104(11):4653-7. PubMed Abstract

Rothenfluh A, Threlkeld RJ, Bainton RJ, Tsai LT, Lasek AW, Heberlein U (2006) Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms. Cell 127(1):199-211. PubMed Abstract

Janak PH, Wolf FW, Heberlein U, Pandey SC, Logrip ML, Ron D (2006) BIG news in alcohol addiction: new findings on growth factor pathways BDNF, insulin, and GDNF. Alcohol Clin Exp Res 30:214-21. PubMed Abstract

Bainton RJ, Tsai, LTY, Schwabe T, DeSalvo M, Gaul U, Heberlein U (2005) moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability in Drosophila. Cell 123:145-156. PubMed Abstract

Scholz H, Franz M, Heberlein U (2005) The hangover gene defines a stress pathway required for ethanol tolerance development. Nature 436:845-7. PubMed Abstract

Corl AB, Rodan AR, Heberlein U (2005) Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster. Nat Neurosci 8:18-19. PubMed Abstract

Berger KH, Heberlein U, Moore MS (2004) Rapid and chronic: two distinct forms of ethanol tolerance in Drosophila. Alcohol Clin Exp Res 10:1469-80. PubMed Abstract

Tsai LT, Bainton RJ, Blau J, Heberlein U (2004) Lmo mutants reveal a novel role for circadian pacemaker neurons in cocaine-induced behaviors. PLoS Biol 12:E408. PubMed Abstract | PDF Article (495 MB)

Cho W, Heberlein U, Wolf FW (2004) Habituation of an odorant-induced startle response in Drosophila. Genes Brain Behav 3:127-37. PubMed Abstract

Guarnieri DJ, Heberlein U (2003) Drosophila melanogaster, a genetic model system for alcohol research. Int Rev Neurobiol 54:199-228. PubMed Abstract

Rothenfluh A, Heberlein U. Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion (2003) Curr Opin Neurobiol 6:639-45. PubMed Abstract

Wolf FW, Heberlein U (2003) Invertebrate models of drug abuse. J Neurobiol 54:161-78. Review. PubMed Abstract

Wolf FW, Rodan AR, Tsai LT, Heberlein U (2002) High-resolution analysis of ethanol-induced locomotor stimulation in Drosophila. J Neurosci 22:11035-44. PubMed Abstract

Rodan AR, Kiger JA Jr, Heberlein U (2002) Functional dissection of neuroanatomical loci regulating ethanol sensitivity in Drosophila. J Neurosci 22:9490-501. PubMed Abstract

Cheng Y, Endo K, Wu K, Rodan AR, Heberlein U, Davis RL (2001) Drosophila fasciclin II is required for the formation of odor memories and for normal sensitivity to alcohol. Cell 105:757-68. PubMed Abstract

Heberlein U (2000) Genetics of alcohol-induced behaviors in Drosophila. Alcohol Res Health 24:185-8. PubMed Abstract

Scholz H, Ramond J, Singh CM, Heberlein U (2000) Functional ethanol tolerance in Drosophila. Neuron 28:261-71. PubMed Abstract

Singh CM, Heberlein U (2000) Genetic control of acute ethanol-induced behaviors in Drosophila. Alcohol Clin Exp Res 24:1127-36. PubMed Abstract

Bainton RJ, Tsai LT, Singh CM, Moore MS, Neckameyer WS, Heberlein U (2000) Dopamine modulates acute responses to cocaine, nicotine and ethanol in Drosophila. Curr Biol 10:187-94. PubMed Abstract

Tecott LH, Heberlein U (1998) Y do we drink? Cell 95:733-5. No abstract available

Moore MS, DeZazzo J, Luk AY, Tully T, Singh CM, Heberlein U (1998) Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell 93:997-1007. PubMed Abstract

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Drosophila eye development

Chanut F, Woo K, Pereira S, Donohoe TJ, Chang SY, Laverty TR, Jarman AP, Heberlein U (2002) Rough eye is a gain-of-function allele of amos that disrupts regulation of the proneural gene atonal during Drosophila retinal differentiation. Genetics 160:623-35. PubMed Abstract

Chanut F, Luk A, Heberlein U (2000) A screen for dominant modifiers of ro(Dom), a mutation that disrupts morphogenetic furrow progression in Drosophila, identifies groucho and hairless as regulators of atonal expression. Genetics 156:1203-17. PubMed Abstract

Heberlein U, Treisman JE (2000) Early retinal development in Drosophila. Results Probl Cell Differ 31:37-50. No abstract available

Borod ER, Heberlein U (1998) Mutual regulation of decapentaplegic and hedgehog during the initiation of differentiation in the Drosophila retina. Dev Biol 197:187-97. PubMed Abstract

Heberlein U, Borod ER, Chanut FA (1998) Dorsoventral patterning in the Drosophila retina by wingless. Development 125:567-77. PubMed Abstract

Treisman JE, Heberlein U (1998) Eye development in Drosophila: formation of the eye field and control of differentiation. Curr Top Dev Biol 39:119-58. No abstract available

Treisman JE, Luk A, Rubin GM, Heberlein U (1997) eyelid antagonizes wingless signaling during Drosophila development and has homology to the Bright family of DNA-binding proteins. Genes Dev 11:1949-62. PubMed Abstract

Chanut F, Heberlein U (1997) Retinal morphogenesis in Drosophila: hints from an eye-specific decapentaplegic allele. Dev Genet 20:197-207. PubMed Abstract

Chanut F, Heberlein U (1997) Role of decapentaplegic in initiation and progression of the morphogenetic furrow in the developing Drosophila retina. Development 124:559-67. PubMed Abstract

Chanut F, Heberlein U (1995) Role of the morphogenetic furrow in establishing polarity in the Drosophila eye. Development 121:4085-94. PubMed Abstract

Heberlein U, Moses K (1995) Mechanisms of Drosophila retinal morphogenesis: the virtues of being progressive. Cell 81:987-90. No abstract available

Heberlein U, Singh CM, Luk AY, Donohoe TJ (1995) Growth and differentiation in the Drosophila eye coordinated by hedgehog. Nature 373:709-11. PubMed Abstract

Heberlein U, Penton A, Falsafi S, Hackett D, Rubin GM (1994) The C-terminus of the homeodomain is required for functional specificity of the Drosophila rough gene. Mech Dev 48:35-49. PubMed Abstract

Heberlein U, Wolff T, Rubin GM. (1993) The TGF beta homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina. Cell. 75:913-26. PubMed Abstract

Heberlein U, Hariharan IK, Rubin GM (1993) Star is required for neuronal differentiation in the Drosophila retina and displays dosage-sensitive interactions with Ras1. Dev Biol. 160:51-63. PubMed Abstract

Heberlein U, Mlodzik M, Rubin GM (1991) Cell-fate determination in the developing Drosophila eye: role of the rough gene. Development 112:703-12. PubMed Abstract

Heberlein U, Rubin GM (1991) Star is required in a subset of photoreceptor cells in the developing Drosophila retina and displays dosage sensitive interactions with rough. Dev Biol 144:353-61. PubMed Abstract

Heberlein U, Rubin GM (1990) Structural and functional comparisons of the Drosophila virilis and Drosophila melanogaster rough genes. Proc Natl Acad Sci U S A 87:5916-20. PubMed Abstract

Kimmel BE, Heberlein U, Rubin GM (1990) The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype. Genes Dev 4:712-27. PubMed Abstract

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Alcohol dehydrogenase & other early work

England BP, Heberlein U, Tjian R (1990) Purified Drosophila transcription factor, Adh distal factor-1 (Adf-1), binds to sites in several Drosophila promoters and activates transcription. J Biol Chem 265:5086-94. PubMed Abstract

Moses K, Heberlein U, Ashburner M (1990) The Adh gene promoters of Drosophila melanogaster and Drosophila orena are functionally conserved and share features of sequence structure and nuclease-protected sites. Mol Cell Biol 10:539-48. PubMed Abstract

Heberlein U, Tjian R (1988) Temporal pattern of alcohol dehydrogenase gene transcription reproduced by Drosophila stage-specific embryonic extracts. Nature 331:410-5. PubMed Abstract

Bray SJ, Johnson WA, Hirsh J, Heberlein U, Tjian R (1988) A cis-acting element and associated binding factor required for CNS expression of the Drosophila melanogaster dopa decarboxylase gene. EMBO J 7:177-88. PubMed Abstract

Heberlein U, England B, Tjian R (1985) Characterization of Drosophila transcription factors that activate the tandem promoters of the alcohol dehydrogenase gene. Cell 41:965-77. PubMed Abstract

Brake AJ, Merryweather JP, Coit DG, Heberlein UA, Masiarz FR, Mullenbach GT, Urdea MS, Valenzuela P, Barr PJ (1984) Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 81:4642-6. PubMed Abstract

Urdea MS, Merryweather JP, Mullenbach GT, Coit D, Heberlein U, Valenzuela P, Barr PJ (1983) Chemical synthesis of a gene for human epidermal growth factor urogastrone and its expression in yeast. Proc Natl Acad Sci U S A 80:7461-5. PubMed Abstract

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