Keith Mostov, M.D., Ph.D.

Primary Investigator/ Professor, University of California, San Francisco, Departments of Anatomy, and Biochemistry and Biophysics, Cell Biology Program, and Biomedical Sciences Program.

Mostov CV (MS Word file)

Mostov promotion package (MS Word file)

Mostov trainees (MS Word file)

Paul Brakeman, M.D., Ph.D.

Asst. Prof., UCSF Dept Pediatriatrics

Mechanisms of epithelial morphogenesis during renal development.

Dave Bryant, Ph.D.

I am examining the role of RabGTPases in the morphogenesis of simple epithelial structures (MDCK cysts) and during morphogenetic rearrangements (tubulogenesis). I am using a combined genetic, biochemical, and cell biology approach to understand the a) morphogenetic consequence of RabGTPase function in epithelial cysts and, b) the signaling networks associated with RabGTPase function.

Anirban (Rana) Datta, Ph.D.

The role of Cdc42 in cyst formation in 3D epithelial cell culture. I am also studying the role of other Rho GTPases and their regulatory proteins, GEF's, GAP's and GDI's, in epithelial morphogenesis and polarity.

Dennis Eastburn, Ph.D.

I am studying the role of Rho GTPases and their regulatory proteins, GEF's, GAP's and GDI's, in epithelial morphogenesis and polarity.

Catherine Jacobson, Ph.D.

Nuclear and cytoskeletal rearrangements during EMT and migration of epithelial cells.

Miniji Kim, Ph.D.

Role of Par6 in orientation of epithelial polarity.

Pascale Leroy, Ph.D.

Senior Researcher, CNRS, France

My research  is mainly  focused on the understanding of  the control of Epithelial -Mesenchymal Transition (EMT). In particular,  I am studying the function of the transcription factor s Slug and Snail during EMT using the epithelial  MDCK cells in a three dimensional  (3D) culture  system as a model.

Fernando Martin-Belmonte, Ph.D.

PTEN meidated apical segregation of phosphoinositides and their regulation of epithelial morphogenesis through Cdc42.

Courtney Moreno

Research Technician

Gloria Pedro

Lab Assistant

Annette Shewan, Ph.D.

I am principally interested in understanding the mechanisms that support epithelial morphogenesis. I am studying the contribution of polarity complex components in cyst formation and tubulogenesis.

Tao Su, Ph.D.

My research project is focused on the mechanisms of pIgR regulated pIgA transcytosis in epithelial cells.

Kitty Tang

Staff Research Associate

Naoki Tanimizu, Ph.D.

Bile ducts are tubular structure in the liver.   In order to understand molecular mechanisms governing tubular morphogenesis of bile ducts, I've established a three dimensional culture system in which liver progenitor cells develop multicellular structure similar to bile ducts.

Wei Yu, Ph.D.

Mechanisms for epithelial morphogenesis in three dimensional culture system.