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Publication List
(*most significant)



2007

Lemieux, G. A., F. Blumenkron, N. Yeung, P. Zhou, J. Williams, A. C. Grammer, A. C. Grammer, R. Petrovich, P. E. Lipsky, M. L. Moss & Z. Werb (2007). The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10. J. Biol. Chem. Mar 27 [Epub ahead of print]. PMID: 17389606 PDF

Egeblad, M., H.-C. J. Shen, D. J. Behonick, L. Wilmes, A. Eichten, L. Korets, F. Kheradmand, Z. Werb & L. M. Coussens (2007). Type I collagen is a modifier of matrix metalloproteinase-2 function in skeletal development. Dev. Dyn. In press.

Yu, W., X. Fang, A. J. Ewald, K. Wong, C. A. Hunt, Z. Werb, M. A. Matthay & K.   Mostov (2007). Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Mol. Biol. Cell. Mar 1 [Epub ahead of print]. PMID: 17332496 PDF

Fata, J.E., H. Mori, A. J. Ewald, H. Zhang, E. Yao, Z. Werb & M. J. Bissell (2007). The MAPK ERK-1,2 pathway integrates distinct and antagonistic signals from TGF a and FGF7 in morphogenesis of mouse mammary epithelium. Dev. Biol. [Epub 16 March 2007] doi: 10.1016/j.ydbio.2007.03.013

Gutiérrez-Fernández, A., M. Inada, M. Balbín, A. Fueyo, A. S. Pitiot, A. Astudillo, , K. Hirose, M. Hirata, S. D. Shapiro, A. Noël, Z. Werb, S. M. Krane, C. López-Otín & X. S. Puente (2007). Increased inflammation delays wound healing in MMP-8/collagenase-2 deficient mice.   FASEB J. Mar 28 [Epub ahead of print.] PMID: 17392479 PDF

*Page-McCaw, A., A. J. Ewald & Z. Werb (2007). Matrix metalloproteinases and the regulation of tissue remodelling. Nat. Rev. Mol. Cell Biol. 8: 221-233. PMID: 17318226. Featured article and cover. PDF

Lum, D.H., J.   Tan, S. D. Rosen & Z. Werb . (2007). Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase, Sulf2. Mol. Cell. Biol. 27:678-688. [Epub, 20 Nov 2006]. PMID: 17116694 PDF

2006

*Kouros-Mehr, H., E. M. Slorach, M. D. Sternlicht & Z. Werb (2006). GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell 127:1041-1055. PMID: 17129787. Also see Nature Cell Biol. (News & Views) 9: 135-136 (2007); Nature (News & Views) 445:724-726 (2007). PDF

Greenlee, K., D. B. Corry, D. A. Engler, R. K. Matsunami, P. Tessier,, R. G. Cook, Z. Werb & F. Kheradmand (2006). Proteomics identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation. J. Immunol. 177: 7312-7321. PMID: 17082650 PDF

Sternlicht, M. D., A. M. Dunning, D. H. Moore, P. D. P. Pharoah, D. G. Ginzinger, K. Chin, J. W. Gray, F. M. Waldman, B. A. J. Ponder & Z. Werb (2006). Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression. Canc. Epidemiol. Biomarkers. Prev. 15: 2107-2114. PMID: 17119035 PDF

Chaillan, F.A., S. Rivera, E. Marchetti, J. Jourquin, Z.   Werb. P.D. Soloway, M. Khrestchatisky & F.S. Roman (2006) Involvement of tissue inhibition of metalloproteinases-1 in learning and memory in mice. Behav. Brain Res. 173:191-198. [Epub, Jul 21, 2006] PMID: 16860884 PDF

Yeh, M. W., J.-P. Rougier, J.-W. Park, Q.-Y. Duh, M. Wong, Z. Werb & O. H. Clark (2006). Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A. Endocr. Relat. Cancer. 13:1173-1183. PMID: 17158762 PDF

Hsu, J.-Y. C., R. McKeon,   S. Goussev, Z. Werb, J.-E. Lee, A. Trivedi & L. J. Noble-Haeusslein (2006). Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. J. Neurosci. 26 :9841-9850. PMID: 17005848 [PDF not available]

Lund, L.R., K. A. Green, A. A. Stoop, M. Ploug, K. Almholt, J. Lilla, B. S. Nielsen, I. J. Christensen, C. S. Craik, Z. Werb, K. Danø & J. Rømer. (2006). Plasminogen activation independent of uPA and tPA maintains skin wound healing in gene-deficient mice. EMBO J. 25:2686-2697.   [Epub Jun 8, 2006]. PMID: 16763560 PDF

Jin, D. K., K. Shido, H.-G. Kopp, I. Petit, S. V. Shmelkov, L. M. Young, A. Hooper, H. Amano, S. T. Avecilla, B. Heissig, K. Hattori, F. Zhang, D. J. Hicklin,   Y. Wu, Z. Zhu, A. Dunn, H. Salari, Z. Werb, N. R. Hackett, R. G. Crystal, D. Lyden & S. Rafii (2006). Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nat. Med. 12:557-567. [Epub April 30, 2006]. PMID: 16648859. Corrigendum: (2006). Nat Med. 12:978. PMID: 16892040 PDF

Zeisberg, M., M. Khurana, V. H. Rao, D. Cosgrove, J.-P. Rougier, M. C. Werner, C. F. Shield III,   Z. Werb   & R. Kalluri (2006). Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. PLoS Med. 3:e100 [Epub Mar 7, 2006]. PMID: 16509766 PDF

Uchimura, K., M. Morimoto-Tomita, A.   Bistrup, J. Li, M. Lyon, J.Gallagher, Z. Werb & S. D. Rosen (2006). HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1 and SDF-1. BMC Biochemistry. 7:2 (Epub Jan 17, 2006). PMID: 16417632 PDF

Hartenstein, B., B. T. Dittrich, D. Stickens B. Heyer, T. H. Vu, S. Teurich, M. Schorpp-Kistner, Z. Werb & P. Angel (2006). Epidermal development and wound healing in matrix metalloproteinase-13 deficient mice. J. Invest. Dermatol. 126:486-496   [ Epub Dec 22, 2005]. PMID: 16374453 [PDF not available]

2005

Atabai K., R. Fernandez, X. Huang, A. Ueki, A. Kline, Y. Li, S. Sadatmansoori, C. Smith-Steinhart, W. Zhu, R. Pytela, Z. Werb & D. Sheppard (2005). Mfge8 is critical for mammary gland remodeling during involution. Mol. Biol. Cell. 16 :5528-5537. [Epub Sept 29, 2005 ]. PMID: 16195353 PDF

*Stickens, D., B. M. Zak, N. Rougier, J. D. Esko & Z. Werb (2005). Mice deficient in Ext2 lack heparan sulfate and develop exostoses. Development. 132:5055-5068 [Epub Oct 19, 2005]. PMID: 16236767 PDF

  Morimoto-Tomita, M., K. Uchimura, A. Bistrup, D. H. Lum, M. Egeblad, N. Boudreau, Z. Werb & S. D. Rosen (2005). Sulf-2, an extracellular heparan sulfate endosulfatase, is upregulated during breast cancer progression and is proangiogenic. Neoplasia.   7: 1001-1010 . PMID: 16331886 PDF

*Heissig, B., S. Rafii, Y, Ohki, Y. Sato, T. Rafael, Z. Zhu, D. J Hicklin, H. Ogawa, Z. Werb & K. Hattori (2005). Low-dose irradiation promotes tissue revascularization through Kit-ligand mediated release of VEGF from mast cells and MMP-9-mediated progenitor cell mobilization. J. Exp. Med. 202:739-750 [Epub Sept 12]. PMID: 16157686 PDF

*Song, S., A. J. Ewald, W. Stallcup, Z. Werb & G. Bergers (2005).   PDGFR b + perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nature Cell. Biol. 7: 870-879 [Epub Aug 21]. PMID: 16113679 PDF

*Carlson, T. R., Y. Yan, X. Wu, M.T. Lam, G. L. Tang, L.J. Beverly, L. M. Messina, A. J. Capobianco, Z. Werb & R. Wang (2005). Endothelial expression of constitutively active Notch 4 elicits reversible arteriovenous malformations in adult mice. Proc. Nat. Acad. Sci. USA 102: 9884-9889 [Epub Jun 30]. PMID: 15994223 PDF

*Sternlicht, M.D., S. W. Sunnarborg, H. Kouros-Mehr, Y. Yu, D. C. Lee & Z. Werb (2005). Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development. 132:3923-3933 [Epub Aug 3, 2005.] PMID: 16079154 PDF

*Radisky, D. C., D. D. Levy, L. E. Littlepage, H. Liu, C. M. Nelson, J. E. Fata, D. Leake, E. L. Godden, D. G. Albertson, M.A. Nieto, Z. Werb & M. J. Bissell. (2005). Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature. 436:123-127. PMID: 16001073 PDF

*Ortega, N., D. J. Behonick, C. Colnot, D. H. Cooper & Z. Werb (2005). Galectin-3 is a downstream regulator of MMP-9 function during endochondral bone formation. Mol. Biol. Cell. 16: 3028-6039   [Epub Mar 30]. PMID: 15800063 PDF

Liu, Z., N. Liu, L. A. Diaz, M. Shipley, R. M. Senior & Z. Werb (2005). Synergy between a plasminogen cascade and MMP-9 in autoimmune disease. J. Clin. Invest. 115: 879-887. PMID: 15841177 PDF

Perez, S., D. A. Cano, T. Dao-Pick, J.-P. Rougier, Z. Werb & M. Hebrok (2005). MMP2 and MMP9 are dispensable for pancreatic islet formation and function in vivo. Diabetes 54: 694-701. PMID: 15734845 PDF

Lee, M. M., B. J. Yoon, B. Johnston, K. Osiewicz, B. Bundy, A. M. van Heeckeren, Z. Werb, P. Kube & P. D. Soloway (2005). TIMP-1 regulates resistance to infection. Infection Immun. 73: 661-665. PMID: 15618213 PDF

Masson, V., L. Rodriguez de la Ballina, C. Munaut, B. Wielocks, M. Jost, C. Maillard, S. Blacher, K. Bajo, T. Itoh, Z. Werb, C. Libert, J.-M. Foidart & A. Noël (2005). Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes. FASEB J. 19: 234-236 [Epub Nov 18, 2004]. PMID: 15550552 PDF

2004

*Stickens, D., D. J. Behonick, N. Ortega, B. Heyer, B. Hartenstein, Y. Yu, M. Schorpp-Kistner, A. Fosang, P. Angel & Z. Werb (2004). Altered endochondral bone formation in matrix metalloproteinase-13 deficient mice.   Development 131: 5883-5895. PMID: 15539485 PDF

Corry, D.B., A. Kiss, L.-Z. Song, L. Song, J. Xu, S.-H. Lee, Z. Werb & F.   Kheradmand (2004).   Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression thorough decreased CC chemokines.   FASEB J. 18: 995-997   [Epub April 1, 2004]. PMID: 15059974 PDF

Cases, S., P. Zhou, J. Schillingford, B. S. Wiseman, J.-D. Fish, C.S. Angle, L. Hennighausen,   Z. Werb   & R. V.   Farese, Jr. (2004).   Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues. Development. 131:3047-3055 [Epub May 26, 2004]. PMID: 15163627 PDF

Chantrain, C.F., H. Shimada, S. Groshen, W. Ye, D. R. Shalinsky, Z. Werb, L. M. Coussens & Y. A. DeClerck (2004). Stromal matrix metalloproteinase-9 (MMP-9) regulates the vascular architecture in neuroblastoma by promoting pericyte recruitment. Cancer Res. 64: 1675-1686. PMID: 14996727 PDF

2003

*Li, Y., B. Welm, K. P., S. Huang, M. Chamorro, T. Rowlands, P. Cowin, M. Egeblad, Z. Werb, L. K. Tan, J. Rosen & H. E. Varmus (2003). Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc. Natl. Acad. Sci. USA. 100: 15853-15858. PMID: 14668450 PDF

Man, A. K., L. J. T. Young, J. Tynan, J.   Lesperance, M. Egeblad, Z. Werb, C. A. Hauser, W.   J. Muller, R. D. Cardiff & R. G. Oshima (2003). Ets2-dependent stromal regulation of mouse mammary tumors. Mol. Cell. Biol. 23: 8614-8625. PMID: 14612405 PDF

Lambert, V., B. Wielockx, C. Munaut, C. Galopin, M. Jost, T. Itoh, Z. Werb, A. Baker, C. Libert, J.-M. Foidart , A. Noël & J.-M. Rakic (2003). MMP-2 and MMP-9 synergize in promoting choroidal neovascularization.   FASEB J. 17: 2290-2292. PMID: 14563686 PDF

*Parisi, T., A. R. Beck, N. Rougier, T. McNeil, L. Lucian, Z. Werb & B.   Amati (2003). Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. EMBO J. 22: 4794-4803. PMID: 12970191 PDF

*Wiseman, B.S., M. D. Sternlicht, L. R. Lund, C. M. Alexander, J. Mott, M. J. Bissell, P. Soloway, S. Itohara & Z. Werb (2003). Site-specific positive and negative activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. J. Cell Biol. 162: 1123-1133. PMID: 12975354 PDF

Whetstone, W., J.Y. Hsu, M. Eisenberg, Z. Werb, L. J. Noble-Haeusslein (2003).   The blood-spinal cord barrier after spinal cord injury:   Relation to revascularization and wound healing.   J. Neurosci. Res.74: 227-39. PMID: 14515352 PDF

Goussev, S., J.-Y. C. Hsu, Y. Lin, T. Tjoa, N. Maida, Z. Werb & L. J. Noble-Haeusslein (2003). Differential temporal expression of matrix metalloproteinases after spinal cord injury:   relationship to revascularization and wound healing. J. Neurosurg. 99 (2 Suppl.):188-197. PMID: 12956462 (PDF not available)

Solberg, H., J. Rinkenberger, K. Danø, Z. Werb & L. R. Lund (2003). A functional overlap of plasminogen and MMPs regulates placental development. Development. 130: 4439-4450. PMID: 12900459 PDF

*Hamano, H., M. Zeisberg, H. Sugimoto, J. Lively, Y. Maeshima, C. Yang, R. O. Hynes, Z. Werb, A. Sudhakar & R. Kalluri (2003). Physiological levels of tumstatin, a fragment of collagen IV a 3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via a V b 3 integrin. Cancer Cell. 3:589-601. PMID: 12842087 PDF

*Colnot, C., Z. Thompson, T. Miclau, Z. Werb & J. A. Helms (2003). Altered bone regeneration in the absence of MMP9. Development.   130: 4123-4133. PMID: 12874132 PDF

Affolter, M., S. Bellusci, N. Itoh, B. Shilo, J.-P. Thiery & Z. Werb (2003). Tube or not tube: remodeling epithelial tissues by branching morphogenesis. Dev. Cell.4: 11-18. PMID: 12530959 PDF

2002

*Coussens, L.M. & Z. Werb (2002). Inflammation and cancer. Nature 420:860-867. PMID: 12490959 PDF

*Ortega N. & Z. Werb (2002). New functional roles for non-collagenous domains of basement membrane collagens. J. Cell Sci. 115:4201-4214. PMID: 12376553 PDF

Morimoto-Tomita, M., K. Uchimura, Z. Werb, S. Hemmerich & S. D. Rosen (2002). Cloning and characterization of two extracellular heparin-degrading endosulfatases in mouse and human. J. Biol. Chem. 277: 49175-49185. PMID: 12368295 PDF

Hangai, M., H. Kitaya, J. Xu, C.K. Chan, J.J. Kin, Z. Werb, S.J. Ryan & P.C. Brooks (2002). Matrix metalloproteinase-9 dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis. Am. J. Path. 161: 1429-1437. PMID: 12368215 PDF

Lambert, V., C. Munaut, M. Jost, A. Noël, Z. Werb, J.-M. Foidart & J.-M. Rakic (2002). Matrix metalloproteinase-9 contributes to choroidal neovascularization.   Am. J. Path.161: 1247-1253. PMID: 12119356 PDF

*Weaver, V. M., S. Lelièvre, J. N. Lakins, M. A. Chrenek, J.C.R. Jones, F. Giancotti, Z. Werb & M.J. Bissell (2002). b 4 Integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell. 2: 205-216. PMID: 12242153 PDF

*Hattori, K., B. Heissig, Y. Wu, S. Dias, R. Tejada, B. Ferris, D. J. Hicklin, Z. Zhu, P. Bohlen, L. Witte, P. J. Hendrikx, N. R. Hackett, R. G. Crystal, M.A.S. Moore, Z. Werb, D. Lyden & S. Rafii (2002). Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment. Nature Med. 8:841-849. PMID: 12091880 PDF

*Yan, Y., Shirakabe K. & Z. Werb (2002). The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G-protein coupled receptors. J. Cell Biol. 158: 221-226. PMID: 12119356 PDF

*Werner, E. & Z. Werb (2002). Integrins engage mitochondrial function for signal transduction by a Rho GTPase-dependent mechanism. J. Cell Biol. 158: 357-368. PMID: 12119354 PDF

*Heissig, B., K. Hattori, S. Dias, M. Friedrich,   B. Ferris, N. R. Hackett, R. G. Crystal, P. Besmer, D. Lyden, M.A. Moore, Z. Werb & S. Rafii (2002). Recruitment of stem cells from the bone marrow niche requires MMP-9-mediated release of Kit ligand. Cell. 109: 625-637. PMID: 12062105 PDF

*Noble, L.J., F. Donovan, T. Igarashi, S. Goussev & Z. Werb (2002).   Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J. Neurosci. 22:7526-7535. PMID: 12196576 PDF

*Wiseman, B. & Z. Werb (2002). Stromal effects on mammary gland development and breast cancer.   Science. 296:1046-1049. PMID: 12004111 PDF

*Egeblad, M. & Z. Werb (2002). New roles for the matrix metalloproteinases in the progression of cancer.   Nature Rev. Cancer. 2: 163-176. PMID: 11990853 (PDF not available)

Corry, D.B., K. Rishi, J. Kanellis, A. Kiss, L.-Z. Song, J.   Xu, L. Feng, Z. Werb & F. Kheradmand (2002). Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation   in MMP-2-deficiency. Nat. Immunol. 3:347-353. PMID: 11887181 PDF

2001

Stoll, S.W., S. Kansra, S. Peshick, D. W. Fry, W. R. Leopold, J. F. Wiesen, M. Sibilia, T. Zhang, Z.   Werb, R. Derynck,   E. F. Wagner   & J. T. Elder (2001). Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes.   Neoplasia 3: 339-350. PMID: 11571634 PDF

*Simian, M. Y. Hirai, M. Navre, Z. Werb, A. Lochter & M. J. Bissell (2001). The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching morphogenesis by mammary epithelial cells.   Development.   128:3117-3131. PMID: 11688561 PDF

Lelongt, B., S. Bengatta, M. Delauche, L.R. Lund, Z. Werb & P. M. Ronco (2001).   MMP9 protects mice from anti-glomerular basement membrane nephritis through its fibrinolytic activity.     J. Exp. Med. 197: 793-802. PMID: 11283152 PDF

*Selvarajan, S., L. R. Lund, T. Takeuchi, C. S. Craik & Z. Werb (2001). A plasminogen cascade dependent on plasma kallikrein is required for adipocyte differentiation.   Nature Cell Biol. 3: 267-275. PMID: 11231576 PDF

*Sternlicht, M.D. & Z. Werb (2001).   How matrix metalloproteinases regulate cell behavior.   Annu. Rev. Cell Dev. Biol. 17: 463-516. PMID: 11687497 PDF

Yamada, E., Tobe, T., H. Yamada, N. Okamoto, D.J. Zack, Z. Werb, P. D. Soloway, and P. A. Campochiaro (2001). TIMP-1 promotes VEGF-induced neovascularization in the retina. Histol.   Histopathol. 16: 87-97. PMID: 11193216 (PDF not available)

2000

Engsig, M.T., Q.-J Chen, T. H. Vu, A.C. Pedersen, B. Therkidsen, L. Lund, K. Henriksen, B. Winding, T. Lenhard, N. T. Foged, Z. Werb & J.-M. Delaissé (2000). Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones. J. Cell Biol. 151:879-889. Erratum in: J Cell Biol 2001 Jan 22;152(2):following 417.PMID: 11076971 PDF

*Coussens, L. M., C. L. Tinkle, D. Hanahan & Z. Werb (2000). MMP-9 supplied by bone marrow-derived cells regulates skin carcinogenesis.   Cell. 103:481-490. PMID: 11081634 PDF

*Bergers, G., R. Brekken, G. McMahon, T.H. Vu, T. Itoh, K. Tamaki, K. Tanzawa, P. Thorpe, S. Itohara, Z. Werb & D. Hanahan (2000). Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis.   Nature Cell Biol. 2: 737-744. PMID: 11025665 PDF

Ducharme, A., S. Frantz, M. Aikawa, E. Rabkin,   M. Lindsey,   L.E.   Rohde, F.J. Schoen, R.A. Kelly, Z. Werb, P. Libby & R.T. Lee (2000). Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. J. Clin. Invest. 106: 55-62. PMID: 10880048 PDF

Pujuguet, P., M. Simian, J. Liaw, R. Timpl, Z. Werb & M.J. Bissell (2000).   Nidogen-1 regulates laminin-1-dependent mammary-specific gene expression.   J. Cell Sci. 113:849-858. PMID: 10671374 PDF

*Liu, Z., X. Zhou, S. D. Shapiro, J. M. Shipley, L. A. Dias, R. M. Senior & Z. Werb (2000). a 1-proteinase inhibitor is the critical substrate for gelatinase B/ MMP-9 in vivo. Cell   102: 647-655. PMID: 11007483 PDF

Lund, L. R, S. F. Bjørn, M. D. Sternlicht, B. S. Nielsen, H. Solberg, P. A. Usner, R. Østerby, I. J. Christensen, T. H. Bugge, R. W. Stephens, K. Dano & Z. Werb (2000).   Lactational development and involution of the mammary gland requires plasminogen. Development. 127:4481-4492. PMID: 11003846 PDF

1999

Oh, L.Y.S., C. Krekoski, D. Edwards, F. Donovan, Z. Werb & V.W. Yong (1999).   Matrix metalloproteinase-9/gelatinase B is required for process outgrowth by oligodendrocytes.   J. Neurosci. 19: 8464-8475. PMID: 10493747 PDF

*Sternlicht, M. D., A. Lochter, C. J. Sympson, B. Huey, J.-P. Rougier, J. W. Gray, D. Pinkel, M. J. Bissell & Z. Werb (1999). The stromal proteinase MMP-3/stromelysin-1 promotes mammary carcinogenesis.   Cell. 98: 137-146. PMID: 10428026 PDF

Coussens, L.M., W. W. Raymond, G. Bergers, M. Laig-Webster, O. Behrendtsen, Z. Werb, G. H. Caughey & D. Hanahan (1999).   Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis.   Genes & Dev. 13:1382-1397. PMID: 10364156. Cover photo. PDF

Bullard, K.M., L. Lund, J. S. Mudgett, T. N. Mellin, T. K. Hunt, B. Murphy, J. Ronan, Z. Werb & M. J. Banda (1999).   Impaired wound contraction in stromelysin-1 deficient mice. Ann. Surg. 230: 260-265. PMID: 10450741 PDF

*Gerber, H.-P., T. H. Vu, A.M. Ryan, J. Kowalski, Z. Werb & N. Ferrara (1999).   VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nature Med. 5: 623-628. PMID: 10371499 PDF

Kornblum, H. I., S. D. Zurcher, Z. Werb, R. Derynck & K. B. Seroogy (1999). Multiple trophic actions of heparin-binding epidermal growth factor-like growth factor (HB-EGF) in the brain. Eur. J. Neurosci. 11: 3236-3246. PMID: 10510187 PDF

Miettinen, P.J., J.R. Chin, L. Shum, H. C. Slavkin. C. F. Shuler, R. Derynck & Z. Werb (1999).   EGF receptor function is necessary for normal craniofacial development and palate closure.   Nature Gen.   22: 69-73. PMID: 10319864 PDF

1998

Sebastian, J, R.G. Richards, P. Petrusz, J.F. Wiesen, Z. Werb, R. Derynck, Y.K. Hom, G.R. Cunha & R.P. DiAugustine (1998). Activation and function of the EGF receptor and ErbB-2 during mammary gland morphogenesis.   Cell Growth Diff.   9: 777-785. PMID: 9751121 PDF

Kornblum, H. I., R. Hussein, J. Wiesen, P. Miettinen, S.D. Zurcher, K. Chow, R. Derynck & Z. Werb (1998). Abnormal astrocyte development and apoptosis of forebrain structures in mice lacking the epidermal growth factor receptor. J. Neurosci. Res. 53: 697-717. PMID: 9753198 PDF

Liu, Z., J. M. Shipley, T. H. Vu, X. Zhou, L. A. Diaz, Z. Werb & R. M. Senior (1998).   Gelatinase B-deficient mice are resistant to experimental bullous pemphigoid.   J. Exp. Med. 188: 475-482. PMID: 9687525 PDF

Thomasset, N., A. Lochter, C.J. Sympson, L.R. Lund, D.R. Williams, O. Behrendtsen, Z. Werb & M.J. Bissell (1998).   Expression of autoactivated stromelysin-1 in mammary glands of transgenic mice leads to a reactive stroma during early development.   Am. J. Path. 153: 457-467. PMID: 9708806 PDF

Yamamoto, H., M. L. Flannery, S. Kupriyanov, J. Pearce, S. R. McKercher, G. W. Henkel, R. A. Maki, Z. Werb & R. G. Oshima. (1998). Defective trophoblast function in mice with a targeted mutation of Ets2. Genes Dev. 12:1315-1326. PMID: 9573048 PDF

*Vu, T. H., J. M. Shipley, G. Bergers, J. E. Berger, J. A. Helms, D. Hanahan, S.D. Shapiro, R.M. Senior & Z. Werb (1998). MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell.   93:411-422. PMID: 9590175 PDF

*Kheradmand, F., E. Werner, P. Tremble, M. Symons & Z. Werb (1998). Role of Rac1 and oxygen radicals in collagenase-1 gene expression induced by cell shape change.   Science. 280: 898-902. PMID: 9572733 PDF

*MacAuley, A., J. C. Cross & Z. Werb (1998).   Reprogramming the cell cycle for endoreduplication in rat trophoblast. Mol. Biol. Cell. 9: 795-807. PMID: 9529378 PDF

Hom, Y. K., P Young, J. F. Wiesen, P. J. Miettinen, R. Derynck, Z. Werb & G. R. Cunha (1998). Uterine and vaginal organ growth requires epidermal growth factor receptor (EGFR) signaling from stroma. Endocrinology.139: 913-921. PMID: 9492020 PDF

1997

Lochter, A., S. Galosy, J. Muschler, N. Freedman, Z. Werb & M.J. Bissell (1997). Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype of mammary epithelial cells.   J. Cell Biol.   139: 1861-1872. PMID: 9412478 PDF

DiSandro, M. J., L. R. Baskin, Y. W. Li, Z. Werb & G. R. Cunha (1997).   Development and regenerative ability of bladder in the transgenic epidermal growth factor receptor gene knockout mouse.   J. Urol. 158. 1058-1065. PMID: 9258142 PDF

Miettinen, P. J., D. Warburton. D. Bu, J.-S. Zhao, J. E. Berger, P. Minoo, T. Koivisto, L. Allen, L. Dobbs, Z. Werb & R. Derynck.(1997)   Impaired lung branching morphogenesis in the absence of functional EGF receptor.   Dev. Biol. 186: 224-236. PMID: 9205141 PDF

*Werb, Z. (1997). ECM and cell surface proteolysis: regulating cellular ecology.   Cell. 91: 439-442. PMID: 9390552 PDF

Lochter, A., A. Srebow, C.J. Sympson, N. Terracio,   Z. Werb & M.J. Bissell (1997). Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties.   J. Biol. Chem. 272:5007-5015. PMID: 9030563 PDF

1996

*Alexander, C.M., E.W. Howard, M.J. Bissell & Z. Werb (1996).   Rescue of mammary epithelial cell apoptosis and entactin degradation by a TIMP-1 transgene.   J. Cell Biol. 135:1669-1677. PMID: 8978831 PDF

Huttenlocher, A., Z. Werb, P. Tremble, P. Huhtala, L. Rosenberg & C.H. Damsky (1996).   Decorin regulates collagenase gene expression in fibroblasts adhering to vitronectin. Matrix Biol. 15 :239-250. PMID: 8892224 PDF

*Alexander, C.M., E.J. Hansell, O. Behrendtsen, M.L. Flannery, N.S. Kishnani, S.P. Hawkes & Z. Werb (1996).   Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation.   Development.   122: 1723-1736. PMID: 8674412 PDF

*Boudreau, N., Z. Werb & M.J. Bissell (1996).   Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle.   Proc. Nat. Acad. Sci., USA 93:3509-3513. PMID: 8622967 PDF

*Lund, L.R., J. Romer, N. Thomasset, H. Solberg, C. Pyke, M.J. Bissell, K. Dano & Z. Werb (1996).   Two distinct phases of apoptosis in mammary gland involution:   Proteinase - independent and -dependent pathways.   Development.   122: 181-193. PMID: 8565829 PDF

1995

Hansell, E.J., S.M. Frisch, P. Tremble, J.P. Murnane & Z. Werb (1995).   Simian virus 40 transformation alters the actin cytoskeleton, expression of matrix metalloproteinases and inhibitors of metalloproteinases, and invasive behavior of normal and ataxia-telangiectasia human skin fibroblasts.   Biochem. Cell Biol.   73: 373-389. PMID: 8703410 (PDF not available)

*Cross, J.C., M.L. Flannery, M.A. Blanar, E. Steingrimsson, N.A. Jenkins, N.G. Copeland, W.J. Rutter & Z. Werb (1995).   Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development.   Development. 121: 2513-2523. PMID: 7671815 PDF

*Miettinen, P.J., J.E. Berger, J. Meneses, Y. Phung, R.A. Pedersen, Z. Werb & R. Derynck (1995).   Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor.   Nature.   376: 337-341. PMID: 7630400 PDF

*Huhtala, P., M.J. Humphries, J.B. McCarthy, P.M. Tremble, Z. Werb & C.H. Damsky (1995).   Cooperative signaling by a5b1 and a4b1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin.   J. Cell Biol.   129: 867-879. PMID: 7537277 PDF

*Boudreau, N., C.J. Sympson, Z. Werb & M.J. Bissell (1995).   Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix.   Science.   267:891-893. PMID: 7531366 (PDF not available)

*Tremble, P., C.H. Damsky & Z. Werb (1995).   Components of the nuclear signaling cascade that regulate collagenase gene expression in response to integrin-derived signals.   J. Cell Biol.   129: 1707-1720. PMID: 7790365 PDF

1994

*Cross, J.C., Z. Werb & S.J. Fisher (1994).   Implantation and the placenta:   Key pieces of the development puzzle.   Science.   266:1508-1518. PMID: 7985020 (PDF not available)

Tournier, J.M., M. Polette, J. Hinnrasky, J. Beck, Z. Werb and C. Basbaum (1994).   Expression of gelatinase A, a mediator of extracellular matrix remodeling, by tracheal gland serous cells in culture and in vivo.   J. Biol. Chem.   269:   25454-25464. PMID: 7929245 PDF

*Sympson, C.J., R.S. Talhouk, C.M. Alexander, J.R. Chin, S.M. Clift, M.J. Bissell & Z. Werb (1994).   Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression.   J. Cell Biol. 125: 681-693. Published correction appears in J. Cell Biol. 132: 753 (1996). PMID: 8175886 PDF

1993

Shum, L., Y. Sakakura, P. Bringas, Jr., W. Luo, M.L. Snead, M. Mayo, C. Crohin, S. Millar, Z. Werb, S. Buckley, F.L. Hall, D. Warburton & H.C. Slavkin (1993).   EGF abrogation-induced fusilli-form dysmorphogenesis of Meckel's cartilage during embryonic mouse mandibular morphogenesis in vitro.   Development.   118:   903-917. PMID: 8076525 PDF

Sanchez-Lopez, R., C.M. Alexander, O. Behrendtsen, R. Breathnach & Z. Werb (1993). Role of zinc-binding- and hemopexin domain-encoded sequences in the substrate specificity of collagenase and stromelysin-2 as revealed by chimeric proteins.   J. Biol. Chem. 268: 7238-7247. PMID: 8463259 PDF

1992

Hu, C.C., Y. Sakakura, Y. Sasano, L. Shum, P. Bringas, Jr., Z. Werb, & H.C. Slavkin (1992).   Endogenous epidermal growth factor regulates the timing and pattern of embryonic mouse molar tooth morphogenesis.   Int. J. Dev. Biol. 36:505-516. PMID: 1295561 PDF

*Alexander, C.M. & Z. Werb (1992).   Targeted disruption of the tissue inhibitor of metalloproteinases gene increases the invasive behavior of primitive mesenchymal cells derived from embryonic stem cells in vitro.   J. Cell Biol. 118: 727-739. PMID: 1639854 PDF

Rappolee, D.A., K.S. Sturm, O. Behrendtsen, G.A. Schultz, R.A. Pedersen & Z. Werb (1992).   Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos.   Genes Dev. 6: 939-952. PMID: 1317321 PDF

Warburton, D., R. Seth, L. Shum, P.G. Horcher, F.L. Hall, Z. Werb & H.C. Slavkin (1992).   Epigenetic role of epidermal growth factor expression and signalling in embryonic mouse lung morphogenesis.   Dev. Biol. 149: 123-133. PMID: 1728582 PDF Not Available

1991

*Librach, C.L., Z. Werb, M.L. Fitzgerald, K. Chiu, N.M. Corwin, R.A. Esteves, R.A. Grobelny, R. Galardy, C.H. Damsky & S.J. Fisher (1991).   92-kD type IV collagenase mediates invasion of human cytotrophoblasts.   J. Cell Biol. 113: 437-449. PMID: 1849141 PDF

Talhouk, R.S., J.R. Chin, E.N. Unemori, Z. Werb & M.J. Bissell (1991).   Proteinases of the mammary   gland:   Developmental regulation in vivo and vectorial secretion in culture. Development. 112: 439-449. PMID: 1794314 PDF

1990

Hahnel, A.C., D.A. Rappolee, J.L. Millan, T. Manes, C.A. Ziomek, N.G. Theodosiou, Z. Werb, R.A. Pedersen & G.A. Schultz (1990).   Two alkaline phosphatase genes are expressed during early development in the mouse embryo.   Development. 110: 555-564. PMID: 2133555 PDF

Handagama, P., D.A. Rappolee, Z. Werb, J. Levin & D.F. Bainton (1990).   Platelet _-granule fibrinogen, albumin, and immunoglobulin G are not synthesized by rat and mouse megakaryocytes. J. Clin. Invest. 86: 1364-1368. PMID: 2212018 PDF

1989

*Werb, Z., P.M. Tremble, O. Behrendtsen, E. Crowley & C.H. Damsky (1989). Signal transduction through the fibronectin receptor induces metalloproteinase gene expression.   J. Cell Biol. 109: 877-889. PMID: 2547805 PDF

Brenner, C.A., R.R. Adler, D.A. Rappolee, R.A. Pedersen & Z. Werb (1989).   Genes for extracellular matrix-degrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammalian development.   Genes Dev. 3: 848-859. PMID: 2744464 PDF

1988

*Rappolee, D.A., C.A. Brenner, R. Schultz, D. Mark & Z. Werb (1988).   Developmental expression of PDGF, TGF- a , and TGF- b genes in preimplantation mouse embryos.   Science. 241: 1823-1825. PMID: 3175624 PDF not available

*Rappolee, D.A., D. Mark, M.J. Banda & Z. Werb (1988).   Wound macrophages express TGF- a and other growth factors in vivo. Analysis by mRNA phenotyping.   Science. 241: 708-712. PMID: 3041594 PDF not available

1987

*Frisch, S.M., E.J. Clark & Z. Werb   (1987).   Coordinate regulation of stromelysin and collagenase genes determined with cDNA probes.   Proc. Natl. Acad. Sci. USA. 84: 2600-2604. PMID: 3033652 PDF

1986

*Unemori, E.N. & Z. Werb (1986).   Reorganization of polymerized actin: a possible trigger for induction of procollagenase in fibroblasts cultured in and on collagen gels.   J. Cell Biol. 103: 1021-1031. PMID: 3017994 PDF

*Herron, G.S., M.J. Banda, E.J. Clark, J. Gavrilovic & Z. Werb (1986).   Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.   J. Biol. Chem. 261: 2814-2818. PMID: 3005266 PDF

1985

*Chin, J.R., G. Murphy & Z. Werb (1985).   Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.   J. Biol. Chem. 260: 12367-12376. PMID: 2995374 PDF

1984

*Aggeler, J., S.M. Frisch & Z. Werb (1984).   Changes in cell shape correlate with collagenase gene expression by rabbit synovial fibroblasts.   J. Cell Biol. 98: 1662-1671. PMID: 6327718 PDF

1983

*Knighton, D.R., T.K. Hunt, H. Scheuenstuhl, B.J. Halliday, Z. Werb & M.J. Banda (1983).   Oxygen tension modulates expression of angiogenesis factor by macrophages.   Science. 221: 1283-1285. PMID: 6612342 PDF not available

Glass, R.H., J. Aggeler, A.I. Spindle, R.A. Pedersen & Z. Werb (1983).   Degradation of extracellular matrix by mouse trophoblast outgrowths:   A model for implantation.   J. Cell Biol. 96: 1108-1116. PMID: 6339525 PDF

1982

*Banda, M.J., D.R. Knighton, T.K. Hunt & Z. Werb (1982).   Isolation of a nonmitogenic angiogenesis factor from wound fluid.   Proc. Natl. Acad. Sci. U.S.A. 79: 7773-7777. PMID: 6961449 PDF

*Aggeler, J. & Z. Werb (1982).   Initial events in phagocytosis by macrophages viewed from outside and inside the cell:   Particle-membrane binding and clathrin.   J. Cell Biol. 94: 613-623. PMID: 6813339 PDF

*Li, G.C. & Z. Werb (1982). Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts.   Proc. Natl. Acad. Sci. U.S.A. 79: 3218-3222. PMID: 6954473 PDF

Seaman, W.E., T.D. Gindhart, M.A. Blackman, B. Dalal, N. Talal & Z. Werb (1982). Suppression of human natural killing by monocytes and polymorphonuclear leukocytes: Requirement for reactive metabolites of oxygen.   J. Clin. Invest. 69: 876-888. PMID: 7076851 PDF

1981

Seaman, W.E., T.D. Gindhart, M.A. Blackman, B. Dalal, N. Talal & Z. Werb (1981). Natural killing of tumor cells by human peripheral blood cells: suppression of killing in vitro by tumor promoting phorbol diesters.   J. Clin. Invest. 67: 1324-1333. PMID: 6939690 PDF

1980

*Banda, M.J., E.J. Clark & Z. Werb (1980).   Limited proteolysis by macrophage elastase inactivates human a 1-proteinase inhibitor.   J. Exp. Med. 152: 1563-1570. PMID: 6969773  PDF not available

*Werb, Z., D.F. Bainton & P.A. Jones (1980).   Degradation of connective tissue matrices by macrophages. III.   Morphological and biochemical studies on extracellular, pericellular, and intracellular events in matrix proteolysis by macrophages in culture.   J. Exp. Med. 152: 1537-1553. PMID: 7005386 PDF not available

1977

*Werb, Z., C.L. Mainardi, C.A. Vater & E.D. Harris, Jr. (1977).   Endogenous activation of latent collagenase by rheumatoid synovial cells. Evidence for a role for plasminogen activator.   New Engl. J. Med. 296: 1017-1023. PMID: 66627 PDF not available

1975

*Harris, E.D., Jr., J.J. Reynolds & Z. Werb (1975).   Cytochalasin B increases collagenase production by cells in vitro.   Nature 257: 243-244. PMID: 169478 PDF not available

*Werb, Z. & S. Gordon (1975).   Elastase secretion by stimulated macrophages. Characterization and regulation.   J. Exp. Med. 142: 361-377. PMID: 167096 PDF not available

*Werb, Z. & S. Gordon (1975).   Secretion of a specific collagenase by stimulated macrophages.   J. Exp. Med. 142: 346-360. PMID: 167095 PDF not available

1972

*Werb, Z. & Z.A. Cohn (1972).   Cholesterol metabolism in the macrophage.   III. Ingestion and intracellular fate of cholesterol and cholesterol esters.   J. Exp. Med. 135: 21-44. PMID: 4550608 PDF not available

 Peer-reviewed articles (most significant *):

2007

Atabai, K., D. Sheppard & Z. Werb   (2007). The role of the innate immune system in mammary gland remodeling during involution. J. Mamm. Gland Biol. Neoplasia. 12: 37-45 [Feb 8 Epub ahead of print]. PMID: 17286210 PDF

Greenlee, K. J., Z. Werb & F. Kheradmand (2007). Matrix metalloproteinases in lung: Multiple, multifarious and multifaceted. Physiol. Rev. 87: 69-98. PMID: 17237343 PDF

2006

Kouros-Mehr, H. & Z. Werb (2006). Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Dev Dyn. 235: 3404-3412. [Epub Oct 12, 2006].   PMID: 17039550 PDF

Lu, P., M. D. Sternlicht & Z. Werb (2006). Comparative mechanisms of branching morphogenesis in diverse systems. J. Mamm. Gland Biol. Neoplasia. 11:213-228. Epub Nov 21, 2006. PMID: 17120154 PDF

Sternlicht, M.D., H. Kouros-Mehr, P. Lu & Z. Werb (2006). Hormonal and local control of mammary branching morphogenesis. Differentiation. 74 :365-381. PMID: 16916375 PDF

2005

Wall, S., E. Werner, Z. Werb & Y. A. DeClerck (2005).    Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen. J. Biol. Chem. 280:40187-40194   [Epub S ept 2005]. PMID: 16186104 PDF

2004

Wang, K., H. Yamamoto, J. R. Chin, Z. Werb & T. H. Vu (2004) EGFR-deficient mice have delayed vascular invasion and primary endochondral ossification due to defective osteoclast recruitment.   J. Biol. Chem. 279: 53848-53856 [Epub Sept 28, 2004]. PMID: 15456762 PDF

Mott, J.D. and Z. Werb (2004). Regulation of matrix biology by matrix metalloproteinases. Curr. Opin. Cell Biol. 16: 558-564. PMID: 15363807 PDF

Ortega, N., D. J. Behonick & Z. Werb (2004). Matrix remodeling during endochondral ossification. Trends Cell Biol. 14: 86-93. PMID: 15102440 PDF

2003

Behonick, D. J. & Z. Werb (2003). A bit of give and take: the relationship between the extracellular matrix and the developing chondrocyte. Mech. Dev. 129: 1327-1336. PMID: 14623441 PDF

Luk, H.W., L. J. Noble & Z. Werb (2003). Macrophages contribute to the maintenance of stable regenerating neurites following peripheral nerve injury. J. Neurosci. Res. 73:644-658. PMID: 12929132 PDF

Vu, T.H. & Z. Werb (2003). New insights into saccular development and vascular formation in lung allografts under the renal capsule. Mech. Dev. 120: 305-313. PMID: 12591600 PDF

2002

Kheradmand, F., K. Rishi & Z. Werb (2002).   Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2. J. Cell Sci.115: 839-848. PMID: 11865039 PDF

2001

Chen, R., M. G. Fleming, L. A. Diaz, Z. Werb & Z. Liu (2001). Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid. J. Clin. Invest. 108:1151-1158. PMID: 11602622 PDF

Werner, E., F. Kheradmand, R. R. Isberg & Z.   Werb (2001). Phagocytosis mediated by Yersinia invasin in rabbit synovial fibroblasts induces collagenase-1 expression through a pro-inflammatory cascade. J. Cell Sci. 114: 3333-3343. PMID: 11591821 PDF

Alexander, C.M., S. Selvarajan, J. Mudgett & Z. Werb (2001). Stromelysin-1 regulates adipogenesis during mammary gland involution. J. Cell Biol. 152: 693-703. PMID: 11266461 PDF

Chang, C. & Z. Werb (2001). The many faces of metalloproteases: growth signaling, invasion, angiogenesis, and metastasis. Trends Cell Biol. 11: S37-S43. PMID: 11684441 PDF

2000

Heyer, B.S., A. MacAuley, O. Behrendtsen & Z. Werb (2000). Hypersensitivity to DNA damage leads to increased apoptosis during early mouse development.   Genes Dev. 4: 2072-2084. PMID: 10950870 PDF

Vu, T.H. & Z. Werb (2000). Matrix metalloproteinases: effectors of development and normal physiology.   Genes Dev.   14: 2123-2133. PMID: 10970876 PDF

Sternlicht, M.D., M.J. Bissell & Z. Werb (2000).   The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter.   Oncogene 19: 1102-1113. PMID: 10713697 PDF

1999

Lochter, A., Z. Werb & M. J. Bissell (1999). Transcriptional regulation of stromelysin-1 gene expression is altered during progression of mouse mammary epithelial cells from functionally normal to malignant.   Matrix Biol. 18:455-467. PMID: 10601733 PDF

Lochter, A., M. Navre, Z. Werb & M. J. Bissell (1999). a 1 and a 2 integrins mediate invasive activity of mouse mammary carcinoma cells through regulation of stromelysin-1 expression. Mol. Biol. Cell. 10: 271-282. PMID: 9950676 PDF

Wiesen, J. F., P. Young, Z. Werb & G. R. Cunha (1999). Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development. Development 126: 335-344. PMID: 9847247 PDF

Cross, J.C., S. Lam, S. Yagel & Z. Werb (1999). Defective induction of the transcription factor interferon-stimulated gene factor-3   and   interferon a insensitivity in human trophoblast cells. Biol. Reprod. 60: 312-321. PMID: 9915996 PDF

1999

Lukashev, M. E. & Z. Werb (1998).   ECM signaling:   orchestrating cell behavior and misbehavior.   Trends Cell Biol.   8: 437-441. PMID: 9854310 PDF

1997

Rinkenberger, J. L., J. C. Cross & Z. Werb (1997).   Molecular genetics of implantation in the mouse.   Dev. Genet. 21: 6-20. PMID: 9291576 PDF

Chin, J. R. & Werb. Z. (1997).   Matrix metalloproteinases regulate migration, invasion and morphogenesis in epithelium, skeletal muscle and cartilage of the mandibular arch.   Development.   124:1519-1530. PMID: 9108368 PDF

Padgett, L. C., G.-M. Lui, Z. Werb & M. M. LaVail (1997).   Matrix metalloproteinases and tissue inhibitors of metalloproteinases in the retinal pigment epithelium and interphotoreceptor matrix: Vectorial secretion and regulation. Exp. Eye Res.   64: 927-938. PMID: 9301473 PDF

Behrendtsen, O. & Z. Werb (1997).   Metalloproteinases   regulate differentiation and migration of parietal endoderm in mouse embryos.   Dev. Dyn.    208:255-265. PMID: 9022062 PDF

Newman-Smith, E. & Z. Werb (1997).   Functional analysis of trophoblast giant cells in parthenogenetic mouse embryos.   Dev. Genetics.   20: 1-10. PMID: 9094206 PDF

1996

Soloway, P., C.M. Alexander, Z. Werb & R. Jaenisch (1996).   Targeted mutagenesis of TIMP-1 reveals that experimental metastasis is influenced by the TIMP-1 genotype of the tumor but not by that of the host.   Oncogene.13:2307-2314. PMID: 8957071 PDF not available

La Fleur, M., J.L. Underwood, D.A. Rappolee & Z. Werb (1996).   Basement membrane and repair of injury to peripheral nerve:   defining a potential   role for macrophages, matrix metalloproteinases   and tissue inhibitor of metalloproteinases-1.   J. Exp. Med. 184:2311-2326. PMID: 8976186 PDF

Logan, S.K., E.J. Hansell, C.H. Damsky & Z. Werb (1996).   T-Antigen inhibits invasion and metalloproteinase expression in human placental cells transformed with temperature-sensitive simian virus 40.   Matrix Biol. 15: 81-89. PMID: 8837009 PDF

Logan, S.K., M.J. Garabedian, C.E. Campbell & Z. Werb (1996).   Synergistic transcriptional activation of the TIMP-1 promoter via functional interaction of AP-1 and Ets-1 transcription factors.   J. Biol. Chem.   271: 774-782. PMID: 8557686 PDF

1995

Behrendtsen, O., C.M. Alexander & Z. Werb (1995).   Cooperative interactions between extracellular matrix, integrins and parathyroid hormone-related peptide regulate parietal endoderm differentiation in mouse embryos.   Development.   121:4137-4148. PMID: 8575314 PDF

Newman-Smith, E.D. & Z. Werb (1995).   Stem cell defects in parthenogenetic peri-implantation embryos.   Development.   121: 2069-2077. PMID: 7635052 PDF

1994

Rappolee, D.A., C. Basilico, Y. Patel & Z. Werb (1994).   Expression and function of FGF-4 in peri-implantation development in mouse embryos.   Development.   120: 2259-2269. PMID: 7925026 PDF

Tremble, P., R. Chiquet-Ehrismann & Z. Werb (1994).   The extracellular matrix ligands fibronectin and tenascin collaborate in regulating collagenase gene expression in fibroblasts.    Mol. Biol. Cell. 5: 439-453. PMID: 7519905 PDF not available

1993

Tremble, P.M., T.F. Lane, E.H. Sage & Z. Werb (1993).   SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway.   J. Cell Biol. 121: 1433-1444. PMID: 8509459 PDF

MacAuley, A., Werb, Z. and Mirkes, P. (1993).   Characterization of the unusually rapid cell cycles during rat gastrulation.   Development. 117: 873-883. PMID: 8325243 PDF

1992

Talhouk, R.S., M.J. Bissell & Z. Werb (1992).   Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution.   J. Cell Biol. 118: 1271-1282. PMID: 1512297 PDF

Behrendtsen, O., C.M. Alexander & Z. Werb (1992).   Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths.   Development. 114: 447-456. PMID: 1317291 PDF

1991

Nielsen, L.L., Z. Werb & R.A. Pedersen (1991).   Induction of c-fos transcripts in early postimplantation mouse embryos by TGF- a , EGF, PDGF, and FGF.   Mol. Reprod. Devel. 29: 227-237. PMID: 1657054 PDF not available

1990

Crocker, P.R., Z. Werb, S. Gordon & D.F. Bainton (1990).   Ultrastructural localization of a macrophage-restricted sialic acid binding hemagglutinin, SER, in macrophage-hematopoietic cell clusters.   Blood. 76: 1131-1138. PMID: 2205308 PDF

Adler, R.R., C.A. Brenner & Z. Werb (1990).   Expression of extracellular matrix-degrading metalloproteinases and metalloproteinase inhibitors is developmentally regulated during endodermal differentiation of embryonal carcinoma cells.   Development. 110: 211-220. PMID: 2081460 PDF

Unemori, E.N., K.S. Bouhana & Z. Werb (1990).   Vectorial secretion of extracellular matrix proteins, matrix-degrading proteinases and tissue inhibitor of metalloproteinases by endothelial cells.   J. Biol. Chem. 265: 445-451. PMID: 2152926 PDF

Rappolee, D.A. & Z. Werb (1990).   mRNA phenotyping for studying gene expression in small numbers of cells:   Platelet-derived growth factor and other growth factors in wound-derived macrophages.   Am. J. Resp. Cell Mol. Biol. 2: 3-10. Erratum in: Am J Respir Cell Mol Biol 1990 May;2(5):471. PMID: 2407272 PDF not available

1989

Werb, Z. & E.J. Clark (1989).   Phorbol diesters regulate expression of the membrane neutral metalloendopeptidase (EC 3.4.24.11) in rabbit synovial cells and mammary epithelial cells.   J. Biol. Chem. 264: 9111-9113. PMID: 2542298 PDF

Werb, Z., R. Takemura, P.E. Stenberg & D.F. Bainton (1989).   Directed exocytosis of secretory granules containing apolipoprotein E to the adherent surface and basal vacuoles of macrophages spreading on immobile immune complexes.   Am. J. Path. 134: 661-670. PMID: 2923186 PDF

Bainton, D.F., R. Takemura, P. Stenberg & Z. Werb (1989).   Rapid fragmentation and reorganization of Golgi membranes during frustrated phagocytosis of immobile immune complexes by macrophages.   Am. J. Path. 134: 15-26. PMID: 2913823 PDF

Rappolee, D.A., A. Wang, D. Mark & Z. Werb (1989).   A novel method for studying mRNA phenotypes in single or small numbers of cells.   J. Cell. Biochem. 39: 1-11. PMID: 2541142 PDF not available

1988

Unemori, E.N. & Z. Werb (1988).   Collagenase expression and endogenous activation in rabbit fibroblasts stimulated by the calcium ionophore A23187.   J. Biol. Chem. 263:   16252-16259. PMID: 2846541 PDF

1987

Chan, L.-M., C. Hatier, G. Parry, Z. Werb & M.J. Bissell (1987).   Collagen-fibronectin interactions in normal and Rous sarcoma virus-transformed avian tendon cells: Possible mechanisms for increased extracellular matrix turnover after transformation.   In Vitro Cell Devel. Biol. 23: 308-314. PMID: 3032890 PDF not available

Oropeza, R.L., H. Wekerle & Z. Werb   (1987).   Expression of apolipoprotein E by mouse brain astrocytes and its modulation by interferon- g . Brain Res. 410: 45-51. PDF not available

1986

Herron, G.S., Z. Werb, K. Dwyer & M.J. Banda (1986). Secretion of metalloproteinases by stimulated capillary endothelial cells. I. Production of procollagenase and prostromelysin exceeds expression of proteolytic activity.   J. Biol. Chem. 261: 2810-2813. PMID: 3005265 PDF

Werb, Z., R.M. Hembry, G. Murphy & J. Aggeler (1986).   Commitment to expression of the metalloendopeptidases, collagenase and stromelysin: Relationship to inducing events to changes in cytoskeletal architecture.   J. Cell Biol. 102: 697-702. PMID: 3005336 PDF

Takemura, R., P. Stenberg, D.F. Bainton & Z. Werb (1986).   Rapid redistribution of clathrin on macrophage plasma membranes in response to Fc receptor-ligand interaction during frustrated phagocytosis.   J. Cell Biol. 102: 55-69. PMID: 2867099 PDF

1985

Murphy, G. & Z. Werb (1985).   Tissue inhibitor of metalloproteinases: identification of precursor forms synthesized by human fibroblasts in culture.   Biochim. Biophys. Acta. 839: 214-218. PDF not available

Hendler, P.L., P.E. Lavoie, Z. Werb, J. Chan & W.E. Seaman (1985).   Human dendritic cells. Direct observation of transition to fibroblasts.   J. Rheumatol. 12: 660-664. PMID: 3863955 PDF not available

Banda, M.J., E.J. Clark & Z. Werb (1985).   Regulation of a 1-proteinase inhibitor function by alveolar macrophages. Evidence for proteolytic rather than oxidative inactivation. J. Clin. Invest. 75: 1758-1762. PMID: 2989330 PDF

McKerrow, J.H., S. Pino-Heiss, R. Lindquist & Z. Werb (1985).   Purification and characterization of an elastinolytic proteinase secreted by cercariae of Schistosoma mansoni.   J. Biol. Chem. 260: 3703-3707. PMID: 3882713 PDF

Sundsmo, J.S., J.R. Chin, R.A. Papin, D.S. Fair & Z. Werb (1985).   Factor B, the complement alternative pathway proteinase, is a major constitutive protein of resident and elicited mouse macrophages.   J. Exp. Med. 161: 306-322. PMID: 3844438 PDF not available

Murphy, G., J.J. Reynolds & Z. Werb (1985).   Biosynthesis of tissue inhibitor of metalloproteinases by human fibroblasts in culture: Stimulation by 12-O-tetradecanoylphorbol-13-acetate and interleukin 1 in parallel with collagenase.   J. Biol. Chem. 260: 3079-3083. PMID: 2982848 PDF

Frisch, S.M., J. Davidson & Z. Werb (1985).   Blockage of tropoelastin secretion by monensin represses tropoelastin synthesis at a pretranslational level in rat smooth muscle cells.   Mol. Cell. Biol. 5: 253-258. PMID: 3982417 PDF

1984

Cramer, E.B., Z. Werb & D.F. Bainton (1984).   Redistribution of ecto-5'-nucleotidase during phagocytosis by guinea pig polymorphonuclear leukocytes.   J. Leukocyte Biol. 36: 463-475. PMID: 6090556 PDF

Aggeler, J., S.M. Frisch & Z. Werb (1984).   Collagenase is a major gene product of induced rabbit synovial fibroblasts.   J. Cell Biol. 98: 1656-1661. PMID: 6327717 PDF

Takemura, R. & Z. Werb (1984).   Modulation of apoprotein E secretion in response to receptor-mediated endocytosis in resident and inflammatory macrophages.   J. Exp. Med. 159: 167-178. PMID: 6198420 PDF not available

Takemura, R. & Z. Werb (1984).   Regulation of elastase and plasminogen activator secretion in resident and inflammatory macrophages by receptors for the Fc domain of immunoglobulin G and for complement fragments.   J. Exp. Med. 159: 152-166. PMID: 6229594 PDF not available

Takemura, R. & Z. Werb (1984).   Secretory products of macrophages and their physiological functions.   Am. J. Physiol. 246 (Cell Physiol. 15 ): C1-C9. PMID: 6364825 PDF

1983

Werb, Z. (1983).   How macrophages regulate their extracellular environment.   Am. J. Anat. 166: 237-256. PMID: 6846204 PDF not available

Aggeler, J., R. Takemura & Z. Werb (1983).   High resolution three-dimensional views of membrane-associated clathrin and cytoskeleton in critical point-dried macrophages.   J. Cell Biol. 97: 1452-1458. PMID: 6415067 PDF

Werb, Z. & J.R. Chin (1983).   Onset of apoprotein E secretion during differentiation of mouse bone marrow-derived mononuclear phagocytes.   J. Cell Biol. 97: 1113-1118. PMID: 6604729 PDF

Werb, Z. & J.R. Chin (1983).   Endotoxin suppresses expression of apoprotein E by mouse macrophages in vivo and in culture. A biochemical and genetic study.   J. Biol. Chem. 258: 10642-10648. PMID: 6350291 PDF

Werb, Z. & J.R. Chin (1983).   Apoprotein E is synthesized and secreted by resident and thioglycollate-elicited macrophages but not by pyran copolymer- or bacillus Calmette Guerin-activated macrophages.   J. Exp. Med. 158: 1272-1293. PMID: 6619735 PDF not available

Keene, W.E., K.H. Jeong, J.H. McKerrow & Z. Werb (1983).   Degradation of connective tissue matrix by larvae of Schistosoma mansoni. II. Degradation by newly transformed and developing schistosomulae in vitro.   Lab. Invest. 49:201-207. PMID: 6876747 PDF not available

Banda, M.J., E.J. Clark & Z. Werb (1983).   Selective proteolysis of immunoglobulins by mouse macrophage elastase.   J. Exp. Med. 157: 1184-1196. PMID: 6220107  PDF not available

Enders, G., Z. Werb & D.S. Friend (1983).   Lectin binding to sperm zipper particles.   J. Cell Sci. 60: 303-330. PMID: 6874733 PDF

1982

Aggeler, J., L.N. Kapp, S.C.G. Tseng & Z. Werb (1982).   Regulation of protein secretion in Chinese hamster ovary cells by cell cycle position and cell density: plasminogen activator, procollagen and fibronectin.   Exp. Cell Res. 139: 275-283. PMID: 7200903 PDF not available

1981

Aggeler, J., J. Risch & Z. Werb (1981).   Expression of the catalytic activity of plasminogen activator under physiologic conditions.   Biochim. Biophys. Acta 675: 62-68. PMID: 6455162 PDF

Aggeler, J., E. Engvall & Z. Werb (1981).   An irreversible tissue inhibitor of collagenase in human amniotic fluid:   characterization and separation from fibronectin. Biochem.   Biophys. Res. Commun. 100: 1195-1201. PMID: 6268083 PDF not available

Banda, M.J. & Z. Werb (1981).   Mouse macrophage elastase. Purification and characterization as a metalloproteinase.   Biochem. J. 193: 589-605. PMID: 7030312 PDF

1980

Jones, P.A. & Z. Werb (1980).   Degradation of connective tissue matrices by macrophages. II.   Influence of matrix composition on proteolysis of glycoproteins, elastin and collagen.   J. Exp. Med. 152: 1527-1536. PMID: 6450258 PDF not available

Werb, Z., M.J. Banda & P.A. Jones (1980).   Degradation of connective tissue matrices by macrophages. I.   Proteolysis of elastin, glycoproteins, and collagen by proteinases isolated from macrophages.   J. Exp. Med. 152: 1340-1357. PMID: 7000966 PDF not available

1978

Werb, Z., J.T. Dingle, J.J. Reynolds & A.J. Barrett (1978).   Proteoglycan-degrading enzymes of rabbit fibroblasts and granulocytes.   Biochem. J. 173: 949-958. PMID: 30451 PDF

Werb, Z. (1978).   Biochemical actions of glucocorticoids on macrophages in culture. Specific inhibition of elastase, collagenase, and plasminogen activator secretion and effects on other metabolic functions.   J. Exp. Med. 147: 1695-1712. PMID: 210248 PDF not available

Werb, Z., R. Foley & A. Munck (1978).   Interaction of glucocorticoids with macrophages.   Identification of glucocorticoid receptors in monocytes and macrophages.   J. Exp. Med. 147: 1684-1694. PMID: 681878 PDF not available

Werb, Z., R. Foley & A. Munck (1978).   Glucocorticoid receptors and glucocorticoid-sensitive secretion of neutral proteinases in a macrophage line.   J. Immunol. 121: 115-121. PMID: 209106 PDF not available

Werb, Z. & J. Aggeler (1978).   Proteases induce secretion of collagenase and plasminogen activator by fibroblasts.   Proc. Natl. Acad. Sci. USA 75: 1839-1843. PMID: 205872 PDF

Mainardi, C.L. P.H. Levine, Z. Werb & E.D. Harris, Jr. (1978).   Proliferative synovitis in hemophilia. Biochemical and morphological observations.   Arth. Rheum. 21: 137-144. PMID: 623683 PDF not available

1977

Burleigh, M.C., Z. Werb & J.J. Reynolds (1977).   Evidence that species specificity and rate of collagen degradation are properties of collagen not collagenase.   Biochim. Biophys. Acta 494: 198-208. PMID: 198007 PDF not available

1976

Gordon, S. & Z. Werb (1976).   Secretion of macrophage neutral proteinase is enhanced by colchicine.   Proc. Natl. Acad. Sci. USA 73: 872-876. PMID: 176659 PDF

1975

Pirie, A., Z. Werb & M.C. Burleigh (1975).   Collagenase and other proteinases in the cornea of the retinol-deficient rat.   Brit. J. Nutr. 34: 297-309. PMID: 169877 PDF not available

Werb, Z. & J.J. Reynolds (1975).   Rabbit collagenase.   Immunological identity of the enzymes released from cells and tissues in normal and pathological conditions.   Biochem. J. 151: 665-669. PMID: 56176 PDF

Werb, Z. & J.J. Reynolds (1975).   Immunochemical studies with a specific antiserum to rabbit fibroblast collagenase.   Biochem. J. 151: 655-663. PMID: 175786 PDF

Werb, Z. & J.J. Reynolds (1975).   Purification and properties of a specific collagenase from rabbit synovial fibroblasts.   Biochem. J. 151: 645-653. PMID: 175785 PDF

1974

Werb, Z. & J.J. Reynolds (1974).   Stimulation by endocytosis of the secretion of collagenase and neutral proteinase from rabbit synovial fibroblasts.   J. Exp. Med. 140: 1482-1497. PMID: 4372292 PDF not available

Werb, Z., M.C. Burleigh, A.J. Barrett & P.M. Starkey (1974).   The interaction of a 2-macroglobulin with proteinases.   Binding and inhibition of mammalian collagenases and other metal proteinases.   Biochem. J. 139: 359-368. PMID: 4374931 PDF

Werb, Z. & M.C. Burleigh (1974).   A specific collagenase from rabbit fibroblasts in monolayer culture.   Biochem. J. 137: 373-385. PMID: 4363113 PDF

1973

Werb, Z. (1973).   Inhibition of specific collagenase by a 2-macroglobulin.   Biochem. Soc. Trans. 1: 382-383. PDF not available

Werb, Z., M.C. Burleigh & J.J. Reynolds (1973).   Production of a specific collagenase by rabbit synovial cells in continuous cell culture.   Biochem. Soc. Trans. 1: 379. PDF not available

1972

Werb, Z. & Z.A. Cohn (1972).   Plasma membrane synthesis in the macrophage following phagocytosis of polystyrene latex particles.   J. Biol. Chem. 247: 2439-2446. PMID: 5019957 PDF

1971

Werb, Z. & Z.A. Cohn (1971).   Cholesterol metabolism in the macrophage.   II. Alteration of subcellular exchangeable cholesterol compartments and exchange in other cell types.   J. Exp. Med. 134: 1570-1590. PMID: 4942408 PDF not available

Werb, Z. & Z.A. Cohn (1971).   Cholesterol metabolism in the macrophage.   I. The regulation of cholesterol exchange.   J. Exp. Med. 134: 1545-1569. PMID: 5126640 PDF not available