Bieri, Gregor, PhD

Our lab focuses on the brain vasculature as a critical interface between the periphery and the brain. We develop vascular-targeting strategies to maintain and restore brain function in aging and neurodegeneration. Exercise rejuvenates the aging brain partly through circulating blood factors, called exerkines, that act on the blood-brain barrier. Using mouse models together with human iPSC-derived vascular organoid and microfluidics platforms, we investigate how exercise-induced peripheral signals communicate with the brain vasculature. Our long-term goal is to identify vascular targets that protect brain health across the lifespan.