“Unraveling transcription and evolution in hormone-related tumorigenesis”

Dr. Bose is a physician-scientist and practicing medical oncologist.  Our group investigates hormone-related cancers, which possess unexploited vulnerabilities after developing hormone therapy resistance.  We investigate how such tumors dynamically evolve through treatment cycles, and maintain compensatory transcriptional states.  We use these findings to develop rational combinatorial therapies involving both existing and novel approaches.

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